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Published Research

April 26, 2005


[1] Fott, B., Novakova, M.: Studies in Phytology; Academia, Prag 1969, pp 10 - 74

[2] Kashiwa, Y., Tanaka, Y.: Effect of Chlorella on the changes in the body weight and rate of catching cold of the 1966 training fleet crew;

Reportedat the Japan Medical Science Meeting, Nagoya, Japan 1966

[3] Kojima, M., Kasajima, T., Imai, S., Kobayashi, M., Dobashi, M., Uemura, T.: A new Chlorella polysaccharide and its accelerating effect on the phagocytic activity of the reticuloendothelial system; Recent Adv. R.E.S. Res. 1973, 13, 101

[4] Tanaka K., Koga, T., Konishi, F., Nakamura, M., Mitsuyama, M., Himeno, K., Nomoto, K.: Augmentation of host defense by a unicellular green alga, Chlorella vulgaris, to Escherichia coli infection; Infect. Immun. 1986, 53 (2), 267

[5] Hasegawa, T., Tanaka, K., Ueno, K., Ueno, S., Okuda, M., Yoshikai, Y., Nomoto, K.: Augmention of the resistance against Escherichia coli by oral administration of hot water extract of Chlorella vulgaris in rats; Int. J. Immunopharmacol. 1989, 11(8), 971

[6] Hasegawa, T., Okuda, M., Nomoto, K., Yoshikai, Y.: Augmention of the resistance against Listeria monocytogenes by oral administration of a hot water extract of Chlorella vulgaris in mice; Immunopharmacol. Immunotoxicol. 1994, 16(2), 191

[7] Dantas, DC., Kaneno, R., Queiroz, ML.: The effect of Chlorella vulgaris in the protection of mice infected with Listeria moncytogenes. Role of natural killer cells. Immunopharmacol. Immunotoxicol. 1999, 21(3), 609

[8] Dantas, DC., Queiroz, ML.: Effects of chlorella vulgaris on bone marrow pregenitor cells of mice infected with Listeria monocytogenes. Int. J. Immunopharmacol. 1999, 21(8), 499

[9] Konishi, F., Tanaka, K., Kumamoto, S., Hasegawa, T., Okuda, M., Yano, I., Yoshikai, Y., Nomoto, K.: Enhanced resistance against Escherichia coli infection by subcutaneous administration of the hot-water extract of Chlorella vulgaris in cyclophosphamid treated mice. Cancer Imminol. Immunother. 1990; 32(11) 1

[10] Hasegawa, T., Yoshikai, Y., Okuda, M., Nomoto, K.: Accelerated restoration of the leukocyte number and augmented resistance against Escherichia coli in cyclophosphamid – treated rats orally administerd with a hot water extract of Chlorella vulgaris; Int. J. Immunopharmacol. 1990, 12(8), 883

[11] Konishi, F., Mitsuyama, M., Okuda, M., Tanaka, K., Hasegawa, T., Nomoto, K.: Protective effect of an acidic glycoprotein obtained from culture of Chlorella vulgaris against myelosuppression by 5-fluorouracil; Cancer Immunol. Immunother. 1996, 42, 268

[12] Hasegawa, T., Okuda, M., Hiromatsu, K., Nomoto, K., Yoshikai, Y.: Hot water extracts of Chlorella vulgaris reduce opportunistic infection with Listeria monocytogenes in C57BL/6 mice infected with LP-BM% murine leukemia viruses; Int. J. Immunopharmacol. 1995, 17(6), 505

[13] Hasegawa, T., Kimura, Y., Hiromatsu, K., Kobayashi, N., Yamada, A., Makino, M., Okuda, M., Sano, T., Nomoto, K., Yoshikai, K.: Effect of hot water extract of Chlorella vulgaris on cytokine expression patterns in mice with murine acquired immunodefiency syndrome after infection with Listeria monocytogenes; Immunopharmacology 1997, 35(3), 273

[14] Hasegawa, T., Ito, K., Ueno, S., Kumamoto, S., Ando, Y., Yamada, A., Nomato, K., Yaunobu Y.: Oral administration of hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice; Int. J. Immunopharmacol. 1999, 21(5), 311

[15] Ibusuki, K., Minamishima, Y.: Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections; Nat. Immun. Cell Growth. Regul. 1990, 9(2), 121

[16] Yasukawa, K., Akihisa, T., Kanno, H., Kaminaga, T., Izumida, M., Sakoh, T., Tamura, T., Takido, M.: Inhibitory effects of sterols isolated from Chlorella vulgaris on 12-0-tetradecanoylphorbol-13-acetate – induced inflammation and tumor promotion in mouse skin; Biol. Pharm. Bull. 1996, 19(4), 573 

[17] Morimoto, T., Nagatsu, A., Muratami, N., Sakakibara, J., Tokuda, H., Nishino, H., Iwashima, A.: Anti-tumor-promoting glyceroglycolipids from the green alga, Chlorella vulgaris; Phytochemistry 1995, 40(5), 1433 

[18] Tanaka, K., Konishi, F, Hemeno, K., Taniguchi, K., Nomoto, K.: Augmentation of antitumor resistance by stran of unicellular green algae, Chlorella vulgaris; Cancer Immunol. Immunother. 1984, 17(2), 90 

[19] Tanaka, K., Tomita, Y., Tsuruta, M., Konishi, F., Okuda, M., Himeno, K., Nomoto, K.: Oral administration of Chlorella vulgaris augments concomitant antitumor immunity; Immunopharmacol. Immunotoxicol. 1990, 12(2), 277 

[20] Konishi, F., Tanaka, K. Hiemeno, K., Taniguchi, K., Nomoto, K.: Antitumor effect induced by a hot water extract of Chlorella vulgaris (CE): resistance to Meth-A tumor growth mediated by CE –induced polymorphonuclear leukocytes; Cancer Immunol. Immunother. 1985, 19(2), 73 

[21] Noda, K., Ohno, N., Tanaka, K., Kamiya, N., Okuda, M., Yadomae, T., Nomoto, K., Shoyama, Y.: A water-soluble antitumor glycoprotein from Chlorella vulgaris; Planta Med. 1996, 62(5), 423 

[22] Okamoto, M., Kaji, R., Kasetani, H., Yoshida, H., Saito, M., Sato, M.: Purification and characterisation of interferon-gamma-inducing molecule of OK-432, a penicillin-killed streptococcal preparation, by monoclonal antibody neutralizing interferon-gamma-inducing activity of OK-432; J. Immunother 1993, 13(4) 232 

[23] Tsukagoshi, S., Hashimoto, Y., Fujii, G., Kobayashi, H., Nomoto, K., Orita, K.: Krestin (PSK); Cancer Treat. Rev. 1984, 11(2), 131

[24] Noda, K., Ohno, N., Tanaka, K., Okuda, M., Yadomae, T., Nomoto, K., Shoyama, Y.: A new type of Biological Response Modifier from Chlorella vulgaris which needs protein moiety to show an antitumour activity; Phytotherapy Research 1998, 12(5) 309 

[25] Tanaka, K., Yamada, A., Noda, K. Hasegawa, T., Okuda, M., Shoyama, Y., Nomoto, K.: A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation; Cancer Immunol. Immunother. 1998, 45(6), 313 

[26] Rotkovska, D., Vacek, A., Bartonickova, A.: The radioprotective aqueous extract from chlorococcal freshwater algae (Chlorella kessleri) in mice and rats; Strahlenther. Onkol. 1989, 165(11), 813 

[27] Vacek, A., Rotkovska, D., Bartonickova, A.: Radioprotection of hemopoiesis conferred by aqueous extract from chlorococcal algae (Ivastimul) administered to mice before irradiation; Exp. Hematol. 1990, 18(3), 234 

[28] Sarma, L., Tiku, AB., Kesavan, PC., Ogaki, M.: Evaluation of radioprotective action of mutant (E-25) form of Chlorella vulgaris in mice; J. Radiat. Res. 1993, 34(4), 277 

[29] Singh, SP., Tiku, AB., Kesavan, PC.: Post-exposure radioprotection by Chlorella vulgaris (E-25) in mice; Indian J. Exp. Boil. 1995, 33(8), 612 

[30] Merchant, R., Rice, C., Young, H.: Dietary Chlorella pyrenoidosa for patients with malignant glioma: effects of immuno-competence, quality of life, and survival; Phytotherapy Research 1990, 4(6) 220 

[31] Singh, A., Singh, SP., Bamezai, R.: Inhibitory potential of chlorella vulgaris(E-25) on mouse skin papillomagenesis and xenobiotic detoxikation system; Anticancer Res. 1999, 19(3A), 1887 

[32] Singh, A., Singh, SP., Bamezai, R.: Perinatal influence of Chlorella vulgaris (E-25) on hepatic drug metabolizing enzymes and lipid peroxidation: Anticancer Res. 1998, 18(3A), 1509 

[33] Negishi, T., Arimoto, S., Nishizaki, C., Hayatsu, H.: Inhibitory effect of chlorophyll on the gentoxoicity of 3-amino-1-methyl-5H-pyrido[4,3]indole (Trp-P-2); Carcinogenesis 1989, 10(1), 145 

[34] Negishi, T., Rai, H., Hayatsu, H.: Antigenotoxic activity of natural chlorophylls; Mutat. Res. 1997, 376(1-2), 97 

[35] Singh, A., Singh, SP., Bamezai, R.: Modulatory influence of Chlorophyllin on the mouse skin papillomagenesis and xenobiotic detoxication system: Carcinogenesis 1996, 17(7), 1459 

[36] Tanaka, K., Yamada, A., Noda,K., Shoyama, Y., Kubo, C., Nomoto, K.: Oral administration of a unicellular green algae, Chlorella vulgaris, prevents stress-induced ulcer: Planta Med. 1997, 63(5), 465 

[37] Merchant, R., Carmback, C. A., Wise, Ch. M.: Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: A pilot study; Phytotherapy Research 2000, 14, 167 

[38] Okamoto, K., Iizuka, Y., Murakami, T., Miyake, H., Suzuki, T.: Effects of chlorella alkali extract on blood pressure in SHR: Jpn. Heart J. 1978, 19(4), 622 

[39] Sano,T., Tanaka, Y.: Effect of dried, powdered Chlorella vulgaris on experimental atherosclerosis and alimentary hypercholesterolemia in cholesterol-fed rabbits; Artery 1987, 14(2), 76 

[40] Sano, T., Kumamoto, Y., Kamiya, N., Okuda, M., Tanaka, Y.: Effect of lipophilic extract of chlorella vulgaris on alimentary hyperlipide cholesterol-fed rats; Artery 1988, 15(4), 217

[41] Travieso, L., Canizares, RO., Borja, R., Dominguez, AR., Dupeyron, R., Valient, R.: Heavy metal removal by microalgae ; Bull. Environ. Contam. Toxicol. 1999, 62(2), 144 

[42] Chong, AM., Wong, YS., Tam, NF.: Performance of different microalgal species in removing nickel and zinc from industrial wastewater: Chemosphere 2000, 41(1-2), 251 

[43] Krihnamurthy, S., Frederick, RM.: Using biopolymers to remove heavy metals from soil and water; Govt. Reports Announcements & Index (GRA&I), 1994, 13 

[44] Hagino, N., Ichimura, S.: Effect of clorella on fecal and urinary cadmium excretion in “Itai – Itai” disease: Nippon Eiseigaku Zasshi 1975, 30(1)77 

[45] Morita, K., Matsueda, T., Iida, T., Hasegawa, T.: Chlorella accelerates dioxin excretion in rats: J. Nutr. 1999, 129(9), 1731 

[46] Pore, RS.: Detoxification of Chlordecone poisoned rats with chlorella and chlorella derived sporopollenin; Drug. Chem. Toxicol. 1984, 7(1), 57 

[47] Marktl, W.: Micronutrients in cancer prevention; Forsch. Komplementarmed. 1999, 6(5), 248 

[48] Rauma, AL., Torronen, R., Hanninen, O., Mykkanen, H.: Vitamin B12 status of long-term adherents of a strict uncooked vegan diet (“living food diet”) is compromised; J. Nutr. 1995, 125(10), 2511 

[49] Matsuura, E., Nemoto, T., Hozumi, H., Izumi, K., Sait, Y., Ispida, H., Fukimbara, T., Kawahara, H.: Effect of chlorella on rats with iron deficient anemia; Kitasato Arch. Exp. Med. 1991, 64(4), 193

The information contained herein is about dietary supplements, which may be helpful in the maintenance of good health. Dietary supplements are not drugs and are not intended to treat or prevent any specific disease or condition. The information contained herein is for educational purposes only. This is not medical advice and is not intended to replace the advice or attention of healthcare professionals. You should always consult your physician before beginning or making any changes in your diet, supplement or exercise program, for diagnosis and treatment of illness or injuries, and for advice regarding medications. Information contained herein has not been evaluated or pre-approved by the Food and Drug Administration unless specifically so stated.



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